Renal Transplantation in HIV-positive Renal Transplant Recipients: Experience at the Mannheim University Hospital.
Transplant Proc
; 47(9): 2791-4, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26680097
ABSTRACT
Renal transplantation in HIV-positive patients with end-stage renal disease has in recent years become a successful treatment option. We report two patients who underwent renal transplantation using a combination of basiliximab, calcineurin inhibitors, mycophenolate mofetil (MMF), and steroids with a "non-interacting" antiretroviral combination therapy consisting of stavudine or abacavir, lamivudine, and nevirapine. We observed no acute rejection but a BK polyomavirus infection in both patients. In conclusion, a quadruple immunosuppression with an interleukin 2 receptor antagonist, a calcineurin inhibitor, MMF, and steroids appears to be advisable to prevent high rates of acute rejection, but if possible thereafter immunosuppression should be tapered rapidly (eg, MMF stop, prednisolone dose 5 mg/d). The selection of antiretroviral agents should avoid compounds that interact severely with the immunosuppression used.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
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Transplante de Rim
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Rejeição de Enxerto
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Imunossupressores
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Falência Renal Crônica
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article