The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.

Mady, Mohamed S; Mohyeldin, Mohamed M; Ebrahim, Hassan Y; Elsayed, Heba E; Houssen, Wael E; Haggag, Eman G; Soliman, Randa F; El Sayed, Khalid A

Mady, Mohamed S; Mohyeldin, Mohamed M; Ebrahim, Hassan Y; Elsayed, Heba E; Houssen, Wael E; Haggag, Eman G; Soliman, Randa F; El Sayed, Khalid A.

Afiliação

Mady MS; Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.
Mohyeldin MM; Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States.
Ebrahim HY; Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States.
Elsayed HE; Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States.
Houssen WE; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK; Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Haggag EG; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.
Soliman RF; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.
El Sayed KA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States. Electronic address: elsayed@ulm.edu.

Bioorg Med Chem ; 24(2): 113-22, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26692349

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/patologia; Alcaloides Indólicos/farmacologia; Olea/microbiologia; Ovomucina/farmacologia; Penicillium chrysogenum/química; Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores; Animais; Antineoplásicos/química; Antineoplásicos/isolamento & purificação; Linhagem Celular; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células Epiteliais/efeitos dos fármacos; Feminino; Humanos; Alcaloides Indólicos/química; Alcaloides Indólicos/isolamento & purificação; Neoplasias Mamárias Experimentais/tratamento farmacológico; Neoplasias Mamárias Experimentais/patologia; Camundongos; Camundongos Nus; Modelos Moleculares; Estrutura Molecular; Invasividade Neoplásica/patologia; Ovomucina/química; Ovomucina/isolamento & purificação; Proteínas Proto-Oncogênicas c-met/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Bioassay-guided; Breast cancer; Endophyte; Meleagrin; Olive tree; Penicillum chrysogenum; c-Met

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium chrysogenum / Neoplasias da Mama / Ovomucina / Proteínas Proto-Oncogênicas c-met / Alcaloides Indólicos / Olea / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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