Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?
Arch Dis Child
; 101(3): 230-3, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26718815
ABSTRACT
BACKGROUND:
Children with type 1 diabetes mellitus (T1DM) are at increased risk of coeliac disease (CD). Recent guidelines indicate coeliac screening should include HLA typing for CD predisposing (DQ2/DQ8) alleles and those negative for these alleles require no further coeliac screening.METHODS:
Children (n=176) with T1DM attending clinics across two Scottish regions were screened for HLA DQ2/DQ8 as part of routine screening. Data collected included the frequency of DQ2/DQ8 genotypes and the additional cost of HLA screening.RESULTS:
Overall, DQ2/DQ8 alleles were identified in 94% of patients. The additional cost of HLA typing was £3699.52 (£21.02 per patient). All patients with known CD (11/176) were positive for DQ2/DQ8 and all were diagnosed with CD within 5â years of T1DM diagnosis.CONCLUSIONS:
The vast majority of children with T1DM have CD-predisposing HLA genotypes limiting the number of patients that can be excluded from further screening. We conclude that HLA genotyping is not currently indicated for CD screening in this population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Teste de Histocompatibilidade
/
Doença Celíaca
/
Programas de Rastreamento
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Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article