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Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets.
Nachbagauer, Raffael; Miller, Matthew S; Hai, Rong; Ryder, Alex B; Rose, John K; Palese, Peter; García-Sastre, Adolfo; Krammer, Florian; Albrecht, Randy A.
Afiliação
  • Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Faculty of Life Sciences, University of Vienna, Vienna, Austria.
  • Miller MS; Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
  • Hai R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Ryder AB; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Rose JK; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA randy.albrecht@mssm.edu florian.krammer@mssm.edu.
  • Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA randy.albrecht@mssm.edu florian.krammer@mssm.edu.
J Virol ; 90(6): 3268-73, 2015 Dec 30.
Article em En | MEDLINE | ID: mdl-26719251
ABSTRACT
We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Infecções por Orthomyxoviridae / Transmissão de Doença Infecciosa / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Vírus da Influenza A Subtipo H1N1 Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Infecções por Orthomyxoviridae / Transmissão de Doença Infecciosa / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Vírus da Influenza A Subtipo H1N1 Idioma: En Ano de publicação: 2015 Tipo de documento: Article