Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells.

Reif, Raymond; Adawy, Alshaimaa; Vartak, Nachiket; Schröder, Jutta; Günther, Georgia; Ghallab, Ahmed; Schmidt, Marcus; Schormann, Wiebke; Hengstler, Jan G

Reif, Raymond; Adawy, Alshaimaa; Vartak, Nachiket; Schröder, Jutta; Günther, Georgia; Ghallab, Ahmed; Schmidt, Marcus; Schormann, Wiebke; Hengstler, Jan G.

Afiliação

Reif R; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany, reif@ifado.de.
Adawy A; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany.
Vartak N; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany.
Schröder J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Günther G; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany.
Ghallab A; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany, Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, 83523 Qena, Egypt.
Schmidt M; Department of Obstetrics and Gynecology, University Hospital, 55131 Mainz, Germany, and.
Schormann W; Biological Sciences, Sunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Hengstler JG; From the Leibniz Research Centre for Working Environment and Human Factors, 44139 Dortmund, Germany.

J Biol Chem ; 291(8): 3837-47, 2016 Feb 19.

Article em En | MEDLINE | ID: mdl-26719328

Assuntos

Proliferação de Células/fisiologia; Clatrina/metabolismo; Endocitose/fisiologia; Poro Nuclear/metabolismo; Receptor ErbB-3/metabolismo; Transporte Ativo do Núcleo Celular/fisiologia; Proliferação de Células/efeitos dos fármacos; Clatrina/genética; Endocitose/efeitos dos fármacos; Células HEK293; Humanos; Carioferinas/genética; Carioferinas/metabolismo; Neuregulina-1/farmacologia; Poro Nuclear/genética; Receptor ErbB-3/genética; Receptores Citoplasmáticos e Nucleares/genética; Receptores Citoplasmáticos e Nucleares/metabolismo; Transcrição Gênica/efeitos dos fármacos; Transcrição Gênica/fisiologia; Proteína Exportina 1

Palavras-chave

nuclear translocation; proliferation; receptor endocytosis; receptor tyrosine kinase; signal transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clatrina / Receptor ErbB-3 / Poro Nuclear / Proliferação de Células / Endocitose Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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