Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis.
Anticancer Res
; 36(1): 5-12, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26722022
ABSTRACT
BACKGROUND/AIM:
The addition of amifostine to chemoradiotherapy (CRT) or radiotherapy (RT) in advanced, inoperable NSCLC presents varying toxicity. The present study examined amifostine's effect on toxicity and efficacy of CRT or RT alone. MATERIALS ANDMETHODS:
Database searches yielded 16 eligible trials comprising of 1,057 patients. Results of randomised trials were pooled and used to estimate the overall effect.RESULTS:
Amifostine reduced the risk of >grade 2 acute oesophagitis by 26% [risk ratio (RR), 0.74; 95% confidence interval (CI)=0.65-0.86; p<0.0001] and the risk of acute pulmonary toxicity by 44% (RR, 0.56; 95%CI=0.41-0.75; p=0.0001). Risk of complete response was unchanged (RR, 1.64; 95%CI=0.99-2.73; p=0.06), partial response was unchanged (RR, 0.92; 95% CI=0.73-1.16; p=0.48). Statistical heterogeneity was high for toxicity but low for response.CONCLUSION:
Statistical heterogeneity of retrived results casts doubt over amifostine's efficacy in this setting, despite decreased acute oesophageal and pulmonary toxicity. Amifostine did not compromise treatment efficacy.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Protetores contra Radiação
/
Carcinoma Pulmonar de Células não Pequenas
/
Amifostina
/
Quimiorradioterapia
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article