Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with &#916;<sup>9</sup> -tetrahydrocannabinol.

Hoffman, Alexander F; Lycas, Matthew D; Kaczmarzyk, Jakub R; Spivak, Charles E; Baumann, Michael H; Lupica, Carl R

Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with Δ⁹ -tetrahydrocannabinol.

Hoffman, Alexander F; Lycas, Matthew D; Kaczmarzyk, Jakub R; Spivak, Charles E; Baumann, Michael H; Lupica, Carl R.

Afiliação

Hoffman AF; Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Lycas MD; Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Kaczmarzyk JR; Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Spivak CE; Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Baumann MH; Designer Drug Research Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Lupica CR; Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.

Addict Biol ; 22(2): 390-399, 2017 Mar.

Article em En | MEDLINE | ID: mdl-26732435

Assuntos

Agonistas de Receptores de Canabinoides/farmacologia; Canabinoides/farmacologia; Dronabinol/farmacologia; Hipocampo/efeitos dos fármacos; Indóis/farmacologia; Potenciação de Longa Duração/efeitos dos fármacos; Naftalenos/farmacologia; Transmissão Sináptica/efeitos dos fármacos; Animais; Ácido Glutâmico/efeitos dos fármacos; Ácido Glutâmico/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Receptor CB1 de Canabinoide/genética

Palavras-chave

Drug abuse; electrophysiology; marijuana

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dronabinol / Canabinoides / Potenciação de Longa Duração / Transmissão Sináptica / Agonistas de Receptores de Canabinoides / Hipocampo / Indóis / Naftalenos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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