Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.

Naccarati, Alessio; Rosa, Fabio; Vymetalkova, Veronika; Barone, Elisa; Jiraskova, Katerina; Di Gaetano, Cornelia; Novotny, Jan; Levy, Miroslav; Vodickova, Ludmila; Gemignani, Federica; Buchler, Tomas; Landi, Stefano; Vodicka, Pavel; Pardini, Barbara

Naccarati, Alessio; Rosa, Fabio; Vymetalkova, Veronika; Barone, Elisa; Jiraskova, Katerina; Di Gaetano, Cornelia; Novotny, Jan; Levy, Miroslav; Vodickova, Ludmila; Gemignani, Federica; Buchler, Tomas; Landi, Stefano; Vodicka, Pavel; Pardini, Barbara.

Afiliação

Naccarati A; Molecular and Genetic Epidemiology Research Unit, Human Genetics Foundation, Turin, Italy.
Rosa F; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic.
Vymetalkova V; Genomic Variation in Human Populations and Complex Diseases Research Unit, Human Genetics Foundation, Turin, Italy.
Barone E; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic.
Jiraskova K; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Di Gaetano C; Department of Biology, University of Pisa, Pisa, Italy.
Novotny J; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic.
Levy M; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Vodickova L; Genomic Variation in Human Populations and Complex Diseases Research Unit, Human Genetics Foundation, Turin, Italy.
Gemignani F; Department of Medical Sciences, University of Turin, Turin, Italy.
Buchler T; Department of Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Landi S; Department of Surgery, First Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic.
Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic.
Pardini B; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Oncotarget ; 7(17): 23156-69, 2016 Apr 26.

Article em En | MEDLINE | ID: mdl-26735576

Assuntos

Regiões 3' não Traduzidas/genética; Biomarcadores Tumorais/genética; Neoplasias Colorretais/genética; Reparo do DNA/genética; Proteína Homóloga a MRE11/genética; MicroRNAs/genética; Polimorfismo de Nucleotídeo Único; Proteína Rad52 de Recombinação e Reparo de DNA/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Sítios de Ligação; Estudos de Casos e Controles; Neoplasias Colorretais/patologia; Feminino; Seguimentos; Predisposição Genética para Doença; Genótipo; Humanos; Masculino; Pessoa de Meia-Idade; Prognóstico; Taxa de Sobrevida; Adulto Jovem

Palavras-chave

3'UTR polymorphisms; MRE11A; colorectal cancer risk and clinical outcomes; double-strand break repair (DSBR) genes; miRNA binding sites

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Regiões 3' não Traduzidas / Polimorfismo de Nucleotídeo Único / MicroRNAs / Reparo do DNA / Proteína Rad52 de Recombinação e Reparo de DNA / Proteína Homóloga a MRE11 Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google