Calcium leak induced arrhythmias in mouse sino-atrial node and ventricle cells: A simulation study.

ABSTRACT

Bradycardia is found to be a complication during catecholaminergic polymorphic ventricular tachycardia in which calcium leak plays a pivotal role. In this computational study, we determined the effects of sarcoplasmic reticulum calcium leak on the function of sino-atrial node and ventricular model cells.