Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD).
Org Biomol Chem
; 14(5): 1599-610, 2016 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-26741115
ABSTRACT
This study describes general synthesis aspects of fragments for FBDD, as illustrated by the dihydroisoquinolones 1-3. Previous Rh(III) methodology is extended to incorporate amines, heteroatoms (N and S), and substituents (halogen, ester) as potential binding groups and/or synthetic growth points for fragment-to-lead elaboration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Isoquinolinas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article