Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ß2-AR/PI3K/AKT signaling pathway.

Wu, Mei-ping; Zhang, Yi-shuai; Zhou, Qian-mei; Xiong, Jian; Dong, Yao-rong; Yan, Chen

Wu, Mei-ping; Zhang, Yi-shuai; Zhou, Qian-mei; Xiong, Jian; Dong, Yao-rong; Yan, Chen.

Afiliação

Wu MP; Department of Cardiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester,
Zhang YS; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, United States. Electronic address: Yishuai_zhang@outlook.com.
Zhou QM; Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: tazhou@163.com.
Xiong J; Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, United States. Electronic addre
Dong YR; Department of Cardiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China. Electronic address: 1067@szy.sh.cn.
Yan C; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, United States; Department of Cardiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine,

Pharmacol Res ; 104: 115-23, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26746354

Assuntos

Alcaloides/farmacologia; Cardiotônicos/farmacologia; Traumatismo por Reperfusão Miocárdica/metabolismo; Tetra-Hidroisoquinolinas/farmacologia; Alcaloides/uso terapêutico; Animais; Apoptose/efeitos dos fármacos; Apoptose/fisiologia; Cardiotônicos/uso terapêutico; Caspase 3/metabolismo; Células Cultivadas; Peróxido de Hidrogênio; Masculino; Camundongos Endogâmicos C57BL; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Traumatismo por Reperfusão Miocárdica/patologia; Miocárdio/metabolismo; Miocárdio/patologia; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Sprague-Dawley; Receptores Adrenérgicos beta 2/metabolismo; Transdução de Sinais/efeitos dos fármacos; Tetra-Hidroisoquinolinas/uso terapêutico

Palavras-chave

Apoptosis; Beta2-adrenergic receptor; Cardiomyocyte; Higenamine; Higenamine (PubChem CID: 440927); Ischemia/reperfusion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiotônicos / Traumatismo por Reperfusão Miocárdica / Tetra-Hidroisoquinolinas / Alcaloides Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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