[COMPARISON OF PERIOPERATIVE INFLAMMATORY MARKERS BETWEEN PATIENTS WITH ANKYLOSING SPONDYLITIS AND NON-INFLAMMATORY DISEASES UNDERGOING TOTAL HIP ARTHROPLASTY].

ABSTRACT

OBJECTIVE: To evaluate the inflammatory markers in patients with ankylosing spondylitis (AS) or non-inflammatory diseases undergoing total hip arthroplasty (THA) and to ascertain the variation trend of perioperative inflammatory markers and the influence of inflammation markers after THA. METHODS: Between January 2013 and December 2014, 153 consecutive patients with AS were included. According to the range of motion (ROM), the patients were divided into ankylosis group (ROM 0 degrees; group A, n = 92) and stiff group (ROM 3-46 degrees; group B, n = 61); 120 non-inflammatory diseases patients having no bacterial infection and undergoing primary THA served as non-inflammatory group (group C). The inflammatory markers including C-reactive protein (CRP), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR) concentrations were measured before operation and at 1, 3, 5, and 7 days after operation, and the complication was observed. RESULTS: Perioperative serum CRP, IL-6, and ESR increased at first after operation, and then decreased in 3 groups. There were significant differences in CRP and ESR between at pre- and post-operation (P < 0.05); the IL-6 at 1, 3, and 5 days after operation were significantly higher than that at preoperation (P<0.05), but no significant difference was found between at 7 days and at preoperation (P > 0.05). CRP, IL-6, and ESR of group B were significantly higher than those of group A at preoperation (P < 0.05); CRP and IL-6 of groups A and B were significantly higher than those of group C at preoperation and at 1 day after operation (P < 0.05); ESR of groups A and B was significantly higher than that of group C at preoperation, and at 1 day and 3 days after operation (P < 0.05); and no significant difference was shown among 3 groups at the other time points (P > 0.05). No inflammatory activity or increased complication was observed. CONCLUSION: AS and non-inflammatory diseases show similar change trend of inflammatory markers at pre- and post-operation. The inflammatory activity of AS has no significant effect on the changes of inflammation markers and does not increase the incidence of postoperative complications.