Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.
Swiss Med Wkly
; 146: w14222, 2016.
Article
em En
| MEDLINE
| ID: mdl-26752230
ABSTRACT
OBJECTIVE:
To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis.METHODS:
M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases.RESULTS:
Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up.CONCLUSION:
The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia por Mycoplasma
/
DNA Bacteriano
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Encefalite Infecciosa
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Anticorpos Antibacterianos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article