[Prognostic value of the metabolically active tumour volume]. / Valeur pronostique du volume tumoral métabolique sur la TEP au ((18)F)-fluorodésoxyglucose préthérapeutique pour le cancer de l'Åsophage localisé.
Cancer Radiother
; 20(1): 24-9, 2016 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-26762703
ABSTRACT
PURPOSE:
The purpose of this study was to assess the prognostic value of different parameters on pretreatment fluorodeoxyglucose [((18)F)-FDG] positron emission tomography-computed tomography (PET-CT) in patients with localized oesophageal cancer. PATIENTS ANDMETHOD:
We retrospectively reviewed 83 cases of localised oesophageal cancer treated in our institution. Patients were treated with curative intent and have received chemoradiotherapy alone or followed by surgery. Different prognostic parameters were correlated to survival cancer-related factors, patient-related factors and parameters derived from PET-CT (maximum standardized uptake value [SUV max], metabolically active tumor volume either measured with an automatic segmentation software ["fuzzy locally adaptive bayesian" MATVFLAB] or with an adaptive threshold method [MATVseuil] and total lesion glycolysis [TLGFLAB and TLGseuil]).RESULTS:
The median follow-up was 21.8 months (range 0.16-104). The median overall survival was 22 months (95% confidence interval [95%CI] 15.2-28.9). There were 67 deaths 49 associated with cancer and 18 from intercurrent causes. None of the tested factors was significant on overall survival. In univariate analysis, the following three factors affected the specific survival MATVFLAB (P=0.025), TLGFLAB (P=0.04) and TLGseuil (P=0.04). In multivariate analysis, only MATVFLAB had a significant impact on specific survival (P=0.049) MATVFLAB<18 cm(3) 31.2 months (95%CI 21.7-not reached) and MATVFLAB>18 cm(3) 20 months (95%CI 11.1-228.9).CONCLUSION:
The metabolically active tumour volume measured with the automatic segmentation software FLAB on baseline PET-CT was a significant prognostic factor, which should be tested on a larger cohort.Palavras-chave
Automatic segmentation; Cancer de l'Åsophage; FLAB; Facteur pronostique; Metabolically active tumour volume; Oesophageal cancer; Positron emission tomography; Prognostic factor; Quantification; Radiotherapy; Radiothérapie; Segmentation automatique; Tomographie par émission de positons; Volume tumoral métabolique
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
Idioma:
Fr
Ano de publicação:
2016
Tipo de documento:
Article