Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.

Zhang, Bin; Han, Hongyan; Fu, Shilong; Yang, Ping; Gu, Zhenlun; Zhou, Quansheng; Cao, Zhifei

Zhang, Bin; Han, Hongyan; Fu, Shilong; Yang, Ping; Gu, Zhenlun; Zhou, Quansheng; Cao, Zhifei.

Afiliação

Zhang B; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Han H; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Fu S; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Yang P; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Gu Z; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Zhou Q; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University
Cao Z; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, School of Biology and Basic Medical Sciences, Suzhou Institute of Chinese Materia Medica, 2011 Collaborative Innovation Center of Hematology, University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University

Biochem Pharmacol ; 104: 8-18, 2016 Mar 15.

Article em En | MEDLINE | ID: mdl-26774454

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Apoptose/efeitos dos fármacos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Fenantrenos/farmacologia; Neoplasias Gástricas/tratamento farmacológico; Fator 4 Ativador da Transcrição/genética; Animais; Antineoplásicos Fitogênicos/isolamento & purificação; Antineoplásicos Fitogênicos/uso terapêutico; Apoptose/genética; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Chaperona BiP do Retículo Endoplasmático; Estresse do Retículo Endoplasmático/genética; Feminino; Proteínas de Choque Térmico/genética; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/genética; Magnoliopsida/química; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos SCID; Fenantrenos/isolamento & purificação; Fenantrenos/uso terapêutico; Neoplasias Gástricas/genética; Neoplasias Gástricas/patologia; Fator de Transcrição CHOP/genética; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Apoptosis; Dehydroeffusol; ER stress; Gastric cancer; p38

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenantrenos / Neoplasias Gástricas / Apoptose / Estresse do Retículo Endoplasmático / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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