Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity.

Manjasetty, Babu A; Halavaty, Andrei S; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F; Joachimiak, Andrzej

Manjasetty, Babu A; Halavaty, Andrei S; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F; Joachimiak, Andrzej.

Afiliação

Manjasetty BA; European Molecular Biology Laboratory (EMBL), Grenoble Outstation, 71 avenue des Martyrs, F-38042 Grenoble, France; Unit of Virus-Host Cell Interactions (UVHCI), University of Grenoble Alpes, F-38042 Grenoble, France.
Halavaty AS; Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, United States; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States. Electronic address: a-halava
Luan CH; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States; High Throughput Analysis Laboratory, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, United States.
Osipiuk J; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States; Computational Institute, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, United States; Structural Biology Center, Argonne National Laboratory, 9700 South
Mulligan R; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States; Computational Institute, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, United States; Structural Biology Center, Argonne National Laboratory, 9700 South
Kwon K; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States; Infectious Diseases, J. Craig Venter Institute, 9714 Medical Center Dr. Rockville, MD 20850, United States.
Anderson WF; Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, United States; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States.
Joachimiak A; Center for Structural Genomics of Infectious Diseases (CSGID), 303 East Chicago Avenue, Chicago, IL 60626, United States; Computational Institute, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, United States; Structural Biology Center, Argonne National Laboratory, 9700 South

J Struct Biol ; 194(1): 18-28, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26796657

Assuntos

Proteínas de Bactérias/química; Domínios Proteicos; Estrutura Secundária de Proteína; Proteínas Repressoras/química; Sequência de Aminoácidos; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Sítios de Ligação; Clonagem Molecular; Cristalografia por Raios X; Ligação de Hidrogênio; Ligantes; Modelos Moleculares; Ligação Proteica; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Salmonella typhimurium/genética; Salmonella typhimurium/metabolismo; Homologia de Sequência do Ácido Nucleico

Palavras-chave

Loop-to-helix transition; Multidrug resistance; TetR/AcrR; Transcription regulator

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas de Bactérias / Estrutura Secundária de Proteína / Domínios Proteicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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