Bergmann Glia, Long-Term Depression, and Autism Spectrum Disorder.
Mol Neurobiol
; 54(2): 1156-1166, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-26809583
ABSTRACT
Bergmann glia (BG), a specific type of radial astrocytes in the cerebellum, play a variety of vital functions in the development of this structure. However, the possible role of BG in the development of abnormalities observed in individuals with autism spectrum disorder (ASD) seems to be underestimated. One of the most consistent findings observed in ASD patients is loss of Purkinje cells (PCs). Such a defect may be caused by dysregulation of glutamate homeostasis, which is maintained mainly by BG. Moreover, these glial cells are involved in long-term depression (LTD), a form of plasticity which can additionally subserve neuroprotective functions. The aim of presented review is to summarize the current knowledge about interactions which occur between PC and BG, with special emphasis on those which are relevant to the survival and proper functioning of cerebellar neurons.
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Base de dados:
MEDLINE
Assunto principal:
Cerebelo
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Neuroglia
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Depressão Sináptica de Longo Prazo
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Transtorno do Espectro Autista
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article