Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study.
Transfus Apher Sci
; 54(1): 80-4, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26810141
ABSTRACT
We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal.
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Base de dados:
MEDLINE
Assunto principal:
Padrões de Prática Médica
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Neoplasias do Sistema Nervoso Central
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Transplante de Células-Tronco
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Linfoma
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article