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Toward clinical genomics in everyday medicine: perspectives and recommendations.
Delaney, Susan K; Hultner, Michael L; Jacob, Howard J; Ledbetter, David H; McCarthy, Jeanette J; Ball, Michael; Beckman, Kenneth B; Belmont, John W; Bloss, Cinnamon S; Christman, Michael F; Cosgrove, Andy; Damiani, Stephen A; Danis, Timothy; Delledonne, Massimo; Dougherty, Michael J; Dudley, Joel T; Faucett, W Andrew; Friedman, Jennifer R; Haase, David H; Hays, Tom S; Heilsberg, Stu; Huber, Jeff; Kaminsky, Leah; Ledbetter, Nikki; Lee, Warren H; Levin, Elissa; Libiger, Ondrej; Linderman, Michael; Love, Richard L; Magnus, David C; Martland, AnneMarie; McClure, Susan L; Megill, Scott E; Messier, Helen; Nussbaum, Robert L; Palaniappan, Latha; Patay, Bradley A; Popovich, Bradley W; Quackenbush, John; Savant, Mark J; Su, Michael M; Terry, Sharon F; Tucker, Steven; Wong, William T; Green, Robert C.
Afiliação
  • Delaney SK; a Coriell Institute for Medical Research , Camden , NJ , USA.
  • Hultner ML; b Lockheed Martin , Information Systems & Global Solutions , Rockville , MD , USA.
  • Jacob HJ; c HudsonAlpha Institute for Biotechnology , Huntsville , AL , USA.
  • Ledbetter DH; d Geisinger Health System , Danville , PA , USA.
  • McCarthy JJ; e Duke University , Center for Applied Genomics and Precision Medicine , Durham , NC , USA.
  • Ball M; f GenoLogics , Redwood City , CA , USA.
  • Beckman KB; g University of Minnesota , Genomics Center ,, Minneapolis , MN , USA.
  • Belmont JW; h Baylor College of Medicine , Children's Nutrition Research Center , Houston , TX , USA.
  • Bloss CS; i University of California, San Diego , School of Medicine , La Jolla , CA , USA.
  • Christman MF; a Coriell Institute for Medical Research , Camden , NJ , USA.
  • Cosgrove A; j Medullan Inc ., Cambridge , MA , USA.
  • Damiani SA; k Mission Massimo Foundation , Elsternwick , VIC , Australia .
  • Danis T; l Mission Massimo Foundation Inc ., Westlake Village , CA , USA.
  • Delledonne M; m PMed Management, LLC , Phoenix , AZ USA.
  • Dougherty MJ; n University of Verona , 37134 Verona , Italy.
  • Dudley JT; o The American Society of Human Genetics , Bethesda , MD , USA.
  • Faucett WA; p Department of Pediatrics , University of Colorado School of Medicine , Aurora , CO , USA.
  • Friedman JR; q Icahn School of Medicine at Mount Sinai , New York , NY , USA.
  • Haase DH; d Geisinger Health System , Danville , PA , USA.
  • Hays TS; r University of California, San Diego , Departments of Neurosciences and Pediatrics and Rady Children's Hospital , San Diego , CA , USA.
  • Heilsberg S; s Maxwell Clinic , Clarksville , TN , USA.
  • Huber J; t University of Minnesota , Department of Genetics, Cell Biology and Development , Minneapolis , MN , USA.
  • Kaminsky L; j Medullan Inc ., Cambridge , MA , USA.
  • Ledbetter N; u Google Inc ., Mountain View , CA , USA.
  • Lee WH; v Elwood Family Clinic , Elwood , VIC , Australia.
  • Levin E; d Geisinger Health System , Danville , PA , USA.
  • Libiger O; w Life Letters , Sydney , NSW , Australia.
  • Linderman M; q Icahn School of Medicine at Mount Sinai , New York , NY , USA.
  • Love RL; x MD Revolution , San Diego , CA , USA.
  • Magnus DC; q Icahn School of Medicine at Mount Sinai , New York , NY , USA.
  • Martland A; m PMed Management, LLC , Phoenix , AZ USA.
  • McClure SL; y Stanford Center for Biomedical Ethics , Stanford School of Medicine , Stanford , CA , USA.
  • Megill SE; x MD Revolution , San Diego , CA , USA.
  • Messier H; z Genome magazine , Big Science Media , Plano , TX , USA.
  • Nussbaum RL; aa Coriell Life Sciences , Camden , NJ , USA.
  • Palaniappan L; ab Healix Health, Ltd , West Vancouver , BC , Canada.
  • Patay BA; ac Invitae Corp ., San Francisco , CA , USA.
  • Popovich BW; ad Stanford University , Palo Alto , CA , USA.
  • Quackenbush J; ae Scripps Clinic Medical Group , La Jolla , CA , USA.
  • Savant MJ; af Genome British Columbia , Vancouver , BC , Canada.
  • Su MM; ag Dana-Farber Cancer Institute , Boston , MA , USA.
  • Terry SF; ah Savant Wellness , San Francisco , CA , USA.
  • Tucker S; ai Anthem Blue Cross , Woodland Hills , CA , USA.
  • Wong WT; aj Genetic Alliance , Washington , DC , USA.
  • Green RC; ak Novena Specialist Center , Singapore , Republic of Singapore.
Expert Rev Mol Diagn ; 16(5): 521-32, 2016.
Article em En | MEDLINE | ID: mdl-26810587
ABSTRACT
Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare delivery, yet it is currently used in only a small fraction of patients, principally for the diagnosis of suspected Mendelian conditions and for targeting cancer treatments. Given the burden of illness in our society, it is of interest to ask how clinical genome and exome sequencing can be constructively integrated more broadly into the routine practice of medicine for the betterment of public health. In November 2014, 46 experts from academia, industry, policy and patient advocacy gathered in a conference sponsored by Illumina, Inc. to discuss this question, share viewpoints and propose recommendations. This perspective summarizes that work and identifies some of the obstacles and opportunities that must be considered in translating advances in genomics more widely into the practice of medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Genômica / Atenção à Saúde / Medicina de Precisão Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Genômica / Atenção à Saúde / Medicina de Precisão Idioma: En Ano de publicação: 2016 Tipo de documento: Article