Increased levels of brain serotonin correlated with MMP-9 activity and IL-4 levels resulted in severe experimental autoimmune encephalomyelitis (EAE) in obese mice.

Hasan, M; Seo, J-E; Rahaman, K A; Kang, M-J; Jung, B-H; Kwon, O-S

Hasan, M; Seo, J-E; Rahaman, K A; Kang, M-J; Jung, B-H; Kwon, O-S.

Afiliação

Hasan M; Toxicology Laboratory, Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Seo JE; Toxicology Laboratory, Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Rahaman KA; Toxicology Laboratory, Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Kang MJ; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Jung BH; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Kwon OS; Toxicology Laboratory, Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: oskwon@kist.re.kr.

Neuroscience ; 319: 168-82, 2016 Apr 05.

Article em En | MEDLINE | ID: mdl-26820599

Assuntos

Encéfalo/metabolismo; Encefalomielite Autoimune Experimental/complicações; Obesidade/complicações; Serotonina/metabolismo; Animais; Cromatografia Líquida de Alta Pressão; Dieta Hiperlipídica; Encefalomielite Autoimune Experimental/metabolismo; Encefalomielite Autoimune Experimental/patologia; Ensaio de Imunoadsorção Enzimática; Interleucina-4/metabolismo; Masculino; Metaloproteinase 9 da Matriz/metabolismo; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

EAE; MMP-9; NADPH oxidase; dopamine; high-fat diet-induced obesity; serotonin (5-HT)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Serotonina / Encefalomielite Autoimune Experimental / Obesidade Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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