Living on the edge: Simulations of bacterial outer-membrane proteins.
Biochim Biophys Acta
; 1858(7 Pt B): 1753-9, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26826270
ABSTRACT
Gram-negative bacteria are distinguished in part by a second, outer membrane surrounding them. This membrane is distinct from others, possessing an outer leaflet composed not of typical phospholipids but rather large, highly charged molecules known as lipopolysaccharides. Therefore, modeling the structure and dynamics of proteins embedded in the outer membrane requires careful consideration of their native environment. In this review, we examine how simulations of such outer-membrane proteins have evolved over the last two decades, culminating most recently in detailed, highly accurate atomistic models of the outer membrane. We also draw attention to how the simulations have coupled with experiments to produce novel insights unattainable through a single approach. This article is part of a Special Issue entitled Membrane Proteins edited by J.C. Gumbart and Sergei Noskov.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas da Membrana Bacteriana Externa
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Membrana Celular
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Bactérias Gram-Negativas
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Modelos Químicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article