SOXC Genes and the Control of Skeletogenesis.
Curr Osteoporos Rep
; 14(1): 32-8, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26830765
ABSTRACT
The SOXC group of transcription factors, composed of SOX4, SOX11, and SOX12, has evolved to fulfill key functions in cell fate determination. Expressed in many types of progenitor/stem cells, including skeletal progenitors, SOXC proteins potentiate pathways critical for cell survival and differentiation. As skeletogenesis unfolds, SOXC proteins ensure cartilage primordia delineation by amplifying canonical WNT signaling and antagonizing the chondrogenic action of SOX9 in perichondrium and presumptive articular joint cells. They then ensure skeletal elongation by inducing growth plate formation via enabling non-canonical WNT signaling. Human studies have associated SOX4 with bone mineral density and fracture risk in osteoporotic patients, and SOX11 with Coffin-Siris, a syndrome that includes skeletal dysmorphism. Meanwhile, in vitro and mouse studies have suggested important cell-autonomous roles for SOXC proteins in osteoblastogenesis. We here review current knowledge and gaps in understanding of SOXC protein functions, with an emphasis on the skeleton and possible links to osteoporosis.
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Base de dados:
MEDLINE
Assunto principal:
Desenvolvimento Ósseo
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Condrogênese
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Fatores de Transcrição SOXC
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article