Double targeting, controlled release and reversible delivery of daunorubicin to cancer cells by polyvalent aptamers-modified gold nanoparticles.

Taghdisi, Seyed Mohammad; Danesh, Noor Mohammad; Lavaee, Parirokh; Emrani, Ahmad Sarreshtehdar; Hassanabad, Koroush Yousefi; Ramezani, Mohammad; Abnous, Khalil

Taghdisi, Seyed Mohammad; Danesh, Noor Mohammad; Lavaee, Parirokh; Emrani, Ahmad Sarreshtehdar; Hassanabad, Koroush Yousefi; Ramezani, Mohammad; Abnous, Khalil.

Afiliação

Taghdisi SM; Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Danesh NM; Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Research Institute of Sciences and New Technology, Mashhad, Iran.
Lavaee P; Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran; Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran.
Emrani AS; Cardiovascular Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Hassanabad KY; Department of Infectious Disease, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Ramezani M; Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ramezanim@mums.ac.ir.
Abnous K; Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: abnouskh@mums.ac.ir.

Mater Sci Eng C Mater Biol Appl ; 61: 753-61, 2016 Apr 01.

Article em En | MEDLINE | ID: mdl-26838906

Assuntos

Antineoplásicos/química; Aptâmeros de Nucleotídeos/química; Daunorrubicina/química; Portadores de Fármacos/química; Ouro/química; Nanopartículas Metálicas/química; Antineoplásicos/toxicidade; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Daunorrubicina/toxicidade; Humanos; Concentração de Íons de Hidrogênio; Leucemia/metabolismo; Leucemia/patologia; Oligonucleotídeos Antissenso/metabolismo

Palavras-chave

Antisense; Daunorubicin; Gold nanoparticles; Leukemia; Polyvalent aptamers; Targeted delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Daunorrubicina / Aptâmeros de Nucleotídeos / Nanopartículas Metálicas / Ouro / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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