Comparison of adult stem cells derived from multiple stem cell niches.
Biotechnol Lett
; 38(5): 751-9, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26857609
ABSTRACT
OBJECTIVES:
Adult stem cells (ASCs) have great potential for tissue regeneration; however, comparative studies of ASCs from different niches are required to understand the characteristics of each population for their potential therapeutic uses.RESULTS:
We compared the proliferation, stem cell marker expression, and differentiation potential of ASCs from bone marrow, skin dermis, and adipose tissue. ASCs from bone marrow and skin dermis showed 50-100 % increased proliferation in comparison to the ASCs from adipose tissues. Furthermore, ASCs from each stem cell niche showed differential expression of stem cell marker genes, and preferentially differentiated into cell types of their tissue of origin.CONCLUSION:
Different characters of each ASC might be major factors for their effective use for therapeutics and tissue regeneration.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Proliferação de Células
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Células-Tronco Adultas
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Nicho de Células-Tronco
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article