3-Component synthesis of &#945;-substituted sulfonamides via Brønsted acid-catalyzed C(sp(3))-H bond functionalization of 2-alkylazaarenes.

Beisel, T; Kirchner, J; Kaehler, T; Knauer, J; Soltani, Y; Manolikakes, G

3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp(3))-H bond functionalization of 2-alkylazaarenes.

Beisel, T; Kirchner, J; Kaehler, T; Knauer, J; Soltani, Y; Manolikakes, G.

Afiliação

Beisel T; Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany. g.manolikakes@chemie.uni-frankfurt.de.

Org Biomol Chem ; 14(24): 5525-8, 2016 Jun 28.

Article em En | MEDLINE | ID: mdl-26868020

ABSTRACT

ABSTRACT

A Brønsted acid-catalyzed addition of 2-alkylazaarenes to in situ generated N-sulfonylimines through selective C(sp(3))-H bond functionalization has been developed. This protocol provides an atom- and step-economic approach to α-substituted sulfonamides.

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article