Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control.

Steffensen, Maria A; Pedersen, Louise H; Jahn, Marie L; Nielsen, Karen N; Christensen, Jan P; Thomsen, Allan R

Steffensen, Maria A; Pedersen, Louise H; Jahn, Marie L; Nielsen, Karen N; Christensen, Jan P; Thomsen, Allan R.

Afiliação

Steffensen MA; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Pedersen LH; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Jahn ML; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Nielsen KN; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Christensen JP; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Thomsen AR; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark athomsen@sund.ku.dk.

J Immunol ; 196(6): 2666-76, 2016 Mar 15.

Article em En | MEDLINE | ID: mdl-26873995

Assuntos

Linfócitos T CD8-Positivos/imunologia; Vírus da Coriomeningite Linfocítica/imunologia; Vacinas Virais/administração & dosagem; Animais; Linfócitos T CD8-Positivos/virologia; Células Cultivadas; Citotoxicidade Imunológica; Feminino; Humanos; Imunidade Celular; Epitopos Imunodominantes/imunologia; Ativação Linfocitária; Camundongos; Camundongos Endogâmicos C57BL; Nucleoproteínas/imunologia; Proteínas Virais/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Linfócitos T CD8-Positivos / Vírus da Coriomeningite Linfocítica Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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