Contribution of PPAR&#945;/ß/Î³, AP-1, importin-&#945;3, and RXR&#945; to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.

Senol, Sefika Pinar; Temiz, Meryem; Guden, Demet Sinem; Cecen, Pelin; Sari, Ayse Nihal; Sahan-Firat, Seyhan; Falck, John R; Dakarapu, Rambabu; Malik, Kafait U; Tunctan, Bahar

Contribution of PPARα/ß/Î³, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.

Senol, Sefika Pinar; Temiz, Meryem; Guden, Demet Sinem; Cecen, Pelin; Sari, Ayse Nihal; Sahan-Firat, Seyhan; Falck, John R; Dakarapu, Rambabu; Malik, Kafait U; Tunctan, Bahar.

Afiliação

Senol SP; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Temiz M; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Guden DS; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Cecen P; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Sari AN; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Sahan-Firat S; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey.
Falck JR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dakarapu R; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Malik KU; Department of Pharmacology, College of Medicine, Center for Health Sciences, University of Tennessee, Memphis, TN, USA.
Tunctan B; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey. btunctan@gmail.com.

Inflamm Res ; 65(5): 367-87, 2016 May.

Article em En | MEDLINE | ID: mdl-26875149

Assuntos

Anti-Inflamatórios/farmacologia; Lipopeptídeos/farmacologia; Choque Séptico/metabolismo; Animais; Anti-Inflamatórios/uso terapêutico; Aorta Torácica/efeitos dos fármacos; Aorta Torácica/metabolismo; Modelos Animais de Doenças; Ácidos Hidroxieicosatetraenoicos; Hipotensão/tratamento farmacológico; Hipotensão/metabolismo; Rim/efeitos dos fármacos; Rim/metabolismo; Lipopeptídeos/uso terapêutico; Lipopolissacarídeos; Masculino; Artérias Mesentéricas/efeitos dos fármacos; Artérias Mesentéricas/metabolismo; Miocárdio/metabolismo; PPAR alfa/metabolismo; PPAR gama/metabolismo; PPAR beta/metabolismo; Ratos Wistar; Receptor X Retinoide alfa/metabolismo; Choque Séptico/tratamento farmacológico; Taquicardia/tratamento farmacológico; Taquicardia/metabolismo; Fator de Transcrição AP-1/metabolismo; alfa Carioferinas/metabolismo

Palavras-chave

AP-1; Endotoxin; Importin-α3; PPARα/ß/Î³; RXRα; Septic shock

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Choque Séptico / Lipopeptídeos / Anti-Inflamatórios Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google