Growth trend of small uterine fibroids and human chorionic gonadotropin serum levels in early pregnancy: an observational study.
Fertil Steril
; 105(5): 1255-1260, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26876103
ABSTRACT
OBJECTIVE:
To analyze the growth trend of small uterine fibroids during early pregnancy, evaluating the potential factors involved, with particular interest in hCG levels.DESIGN:
Observational study.SETTING:
Tertiary care university hospital. PATIENT(S) Women who had an ultrasound diagnosis of small myomas (diameter, ≥10 mm and ≤50 mm) from January 2007 to December 2013, and who subsequently became pregnant within 1 year. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Three additional ultrasound examinations were performed during early pregnancy (7-8, 10-13, and 20-22 complete gestational weeks, respectively) and the modifications in diameter and volume of each uterine fibroid were recorded. A serial evaluation of hCG serum levels from 5-12 weeks was performed. RESULT(S) From the 109 women who fulfilled the study inclusion/exclusion criteria, a significant increase emerged, both for volume and diameter of the detected fibroids. Specifically, a median growth rate (GR) of 122% was observed during the interval of the first to the second ultrasound, whereas a median GR of 108% was detected during the interval between the second and the third ultrasound, and a median GR of 25% between the third and the fourth ultrasound. A significant positive correlation between hCG levels and diameter (R = 0.69) of myomas between 5 and 12 weeks emerged. CONCLUSION(S) A remarkable nonlinear growth of small fibroids during initial pregnancy was observed, with a faster rate in the first trimester and a slowdown by midpregnancy. Those changes seem to be related to the similar increase of hCG levels until 12 weeks.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uterinas
/
Carga Tumoral
/
Gonadotropina Coriônica
/
Leiomioma
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article