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Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
Pelz, Nicholas F; Bian, Zhiguo; Zhao, Bin; Shaw, Subrata; Tarr, James C; Belmar, Johannes; Gregg, Claire; Camper, DeMarco V; Goodwin, Craig M; Arnold, Allison L; Sensintaffar, John L; Friberg, Anders; Rossanese, Olivia W; Lee, Taekyu; Olejniczak, Edward T; Fesik, Stephen W.
Afiliação
  • Pelz NF; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Bian Z; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Zhao B; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Shaw S; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Tarr JC; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Belmar J; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Gregg C; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Camper DV; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Goodwin CM; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Arnold AL; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Friberg A; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Rossanese OW; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Lee T; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Olejniczak ET; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
  • Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
J Med Chem ; 59(5): 2054-66, 2016 Mar 10.
Article em En | MEDLINE | ID: mdl-26878343

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Descoberta de Drogas / Proteína de Sequência 1 de Leucemia de Células Mieloides / Indóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Descoberta de Drogas / Proteína de Sequência 1 de Leucemia de Células Mieloides / Indóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article