Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis.
J Prosthodont
; 26(1): 19-28, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-26883670
ABSTRACT
PURPOSE:
Chronic inflammatory disorders of the oral cavity, such as periodontitis, were recently linked to systemic immune activation. Since fungal oral infections have not yet been studied in this respect, the aim of our study is to determine whether the local inflammation caused by oral fungal infection of the palatal tissue (denture stomatitis-DS) is associated with the systemic inflammatory response. This question is becoming essential as the population ages. MATERIALS ANDMETHODS:
Peripheral blood of DS patients (n = 20) and control patients (n = 24) was assessed with flow cytometry to determine lymphocyte and monocyte profiles. Intracellular cytometric analysis was carried out to establish cytokine production by T cells. DS was diagnosed based on clinical symptoms of DS such as swelling and redness of oral mucosa, confirmed by microbiological swabs for fungal colonization with Candida species. The control group was recruited from denture users without clinical and microbiological signs of oral infections.RESULTS:
Percentages of peripheral lymphocytes, T cells, monocytes, and their subpopulations were similar in both studied groups. The exception was median percentages of CD25+ T cell subsets, which were significantly lower in DS patients than in control subjects. This reduction was observed in both CD4 T cell subset (16.7% and 28.1%; p = 0.0006) and CD8 T cell subset (4.6% and 7.0%; p = 0.007)CONCLUSIONS:
While DS and associated local fungal infection do not overtly affect activation of monocytes or lymphocytes, the number of CD 25+ T cells is significantly lower in the DS patients, possibly indicating limited potential for the infection clearance in denture-using aging patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Estomatite sob Prótese
/
Subpopulações de Linfócitos T
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Subunidade alfa de Receptor de Interleucina-2
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article