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Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.
Béguelin, C; Vázquez, M; Bertschi, M; Yerly, S; de Jong, D; Gutbrod, K; Rauch, A; Cusini, A.
Afiliação
  • Béguelin C; Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
  • Vázquez M; Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
  • Bertschi M; Department of Neurology , Bern University Hospital and University of Bern.
  • Yerly S; Laboratory of Virology , Geneva University Hospital.
  • de Jong D; Department of Neurology , Bern University Hospital and University of Bern.
  • Gutbrod K; Department of Neurology , Bern University Hospital and University of Bern.
  • Rauch A; Department of Infectious Diseases , Inselspital, Bern University Hospital, University of Bern.
  • Cusini A; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern; Infectious Diseases Unit, Cantonal Hospital, Chur, Switzerland.
Open Forum Infect Dis ; 3(1): ofv210, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26885540
In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article