Proton-Coupled Organic Cation Antiporter Contributes to the Hepatic Uptake of Matrine.

Wu, Chunyong; Sun, Xiaomin; Feng, Chao; Liu, Xiaoying; Wang, Hufang; Feng, Fang; Zhang, Junying

Wu, Chunyong; Sun, Xiaomin; Feng, Chao; Liu, Xiaoying; Wang, Hufang; Feng, Fang; Zhang, Junying.

Afiliação

Wu C; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education (China Pharmaceutical University), Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Sun X; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education (China Pharmaceutical University), Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Feng C; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education (China Pharmaceutical University), Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Liu X; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education (China Pharmaceutical University), Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Wang H; Department of Pharmaceutics of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China.
Feng F; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education (China Pharmaceutical University), Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address: fengfang1@126.com.
Zhang J; Department of Pharmaceutics of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China. Electronic address: ivy366300@hotmail.com.

J Pharm Sci ; 105(3): 1301-6, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26886331

Assuntos

Alcaloides/metabolismo; Alcaloides/farmacologia; Antiporters/metabolismo; Antiporters/farmacologia; Transporte Biológico/fisiologia; Fígado/metabolismo; Proteínas de Transporte de Cátions Orgânicos/metabolismo; Quinolizinas/metabolismo; Quinolizinas/farmacologia; Cátions/farmacologia; Linhagem Celular Tumoral; Células Hep G2; Humanos; Concentração de Íons de Hidrogênio; Fígado/efeitos dos fármacos; Preparações Farmacêuticas/metabolismo; Prótons; Matrinas

Palavras-chave

HepG2 cells; hepatic transport; matrine; proton-coupled organic cation antiporter

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolizinas / Transporte Biológico / Antiporters / Proteínas de Transporte de Cátions Orgânicos / Alcaloides / Fígado Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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