Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain.
Braz J Microbiol
; 47(1): 177-80, 2016.
Article
em En
| MEDLINE
| ID: mdl-26887242
ABSTRACT
We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
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MEDLINE
Assunto principal:
Infecções Estafilocócicas
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Staphylococcus aureus
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Catalase
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Códon sem Sentido
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article