Pepsinogen identification in the middle ear fluid of children with otitis media with effusion.
Kulak Burun Bogaz Ihtis Derg
; 26(2): 73-8, 2016.
Article
em En
| MEDLINE
| ID: mdl-26890709
ABSTRACT
OBJECTIVES:
This study aims to investigate the presence and concentration of pepsin/pepsinogen in middle ear fluid and to discuss the potential mechanisms involved in the pathogenesis of this condition. PATIENTS ANDMETHODS:
A total of 33 children (21 boys, 12 girls; mean age 5.7±2.4 years; range 3 to 13 years) diagnosed with otitis media with effusion and scheduled for operation were enrolled into the study. Fluids aspirated from the middle ear were assessed for the presence of pepsinogen and albumin and blood samples were drawn simultaneously for comparison.RESULTS:
Mean pepsinogen concentration was statistically significantly higher in middle ear fluids compared with serum samples (262.4 ng/mL [range 211.7 ng/mL - 301.1 ng/mL] versus 102.6 ng/mL [range 80.7 ng/mL - 134.5 ng/mL], respectively) (p<0.001). On the other hand, mean albumin concentration was significantly lower (1.1 g/dL [range 0.01 g/dL - 9.5 g/dL] versus 5.8 g/dL [range 0.9 - 9.5 g/dL], respectively) (p<0.001). The highest pepsinogen concentration was detected in patients with purulent effusion (275.3 ng/mL).CONCLUSION:
Our findings support the theory of gastro-esophageal reflux related pepsinogen transition to the middle ear and indicate that pepsinogen may a reliable biochemical marker for the assessment of gastro-esophageal reflux.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Otite Média com Derrame
/
Pepsinogênio A
/
Orelha Média
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article