Bat hepadnaviruses and the origins of primate hepatitis B viruses.
Curr Opin Virol
; 16: 86-94, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26897577
ABSTRACT
The origin of primate HBV (family Hepadnaviridae) is unknown. Hepadnaviruses are ancient pathogens and may have been associated with old mammalian lineages like bats for prolonged time. Indeed, the genetic diversity of bat hepadnaviruses exceeds that of extant hepadnaviruses in other host orders, suggesting a long evolution of hepadnaviruses in bats. Strikingly, a recently detected New World bat hepadnavirus is antigenically related to HBV and can infect human hepatocytes. Together with genetically diverse hepadnaviruses from New World rodents and a non-human primate, these viruses argue for a New World origin of ancestral orthohepadnaviruses. Multiple host switches of bat and primate viruses are evident and bats are likely sources of ancestral hepadnaviruses acquired by primates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hepadnaviridae
/
Vírus da Hepatite B
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Hepatite Viral Animal
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article