Immunomodulators for the treatment of Crohn's disease in adults: optimal use and prospects for future drug treatments.
Expert Rev Clin Immunol
; 12(7): 741-9, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26900725
ABSTRACT
Crohn's disease (CD) requires treatment beyond symptoms by enabling and maintaining mucosal healing and therefore clinical remission. However, with the increasing use of biologics there have been safety concerns and there is a significant cost implication with the early use of biologics. Therefore, it is imperative that patients with severe/complicated disease or poor prognostic factors are treated with an aggressive strategy while all remaining patients should be treated in a step-up strategy. The potential for disease modification with thiopurines and methotrexate is debated in CD when they are used as a monotherapy. In this review we discuss existing and newer therapies that have recently been developed for CD. We will also provide an algorithm for current management of adult CD patients in routine clinical practice.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
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Metotrexato
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Adalimumab
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Infliximab
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Fatores Imunológicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article