Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies.

Planchard, David; Brown, Kathryn H; Kim, Dong-Wan; Kim, Sang-We; Ohe, Yuichiro; Felip, Enriqueta; Leese, Philip; Cantarini, Mireille; Vishwanathan, Karthick; Jänne, Pasi A; Ranson, Malcolm; Dickinson, Paul A

Planchard, David; Brown, Kathryn H; Kim, Dong-Wan; Kim, Sang-We; Ohe, Yuichiro; Felip, Enriqueta; Leese, Philip; Cantarini, Mireille; Vishwanathan, Karthick; Jänne, Pasi A; Ranson, Malcolm; Dickinson, Paul A.

Afiliação

Planchard D; Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94805, Villejuif, France. David.PLANCHARD@gustaveroussy.fr.
Brown KH; Quantitative Clinical Pharmacology, AstraZeneca, Macclesfield, UK.
Kim DW; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kim SW; Department of Oncology, Asan Medical Center, Seoul, Republic of Korea.
Ohe Y; Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Felip E; Department of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain.
Leese P; Quintiles Clinical Research Unit, Quintiles, Overland Park, KS, USA.
Cantarini M; Research and Development, AstraZeneca, Macclesfield, UK.
Vishwanathan K; Quantitative Clinical Pharmacology, AstraZeneca, Waltham, MA, USA.
Jänne PA; Department of Adult Oncology, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ranson M; Formerly of Department of Medical Oncology, Christie Hospital, University of Manchester, Manchester, UK.
Dickinson PA; Quantitative Clinical Pharmacology, AstraZeneca, Macclesfield, UK.

Cancer Chemother Pharmacol ; 77(4): 767-76, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26902828

Assuntos

Antineoplásicos/farmacocinética; Piperazinas/farmacocinética; Inibidores de Proteínas Quinases/farmacocinética; Acrilamidas; Compostos de Anilina; Povo Asiático; Química Farmacêutica; Feminino; Interações Alimento-Droga; Humanos; Masculino; Pessoa de Meia-Idade; Piperazinas/administração & dosagem

Palavras-chave

Bioavailability; Food effect; Multiple dose; Osimertinib; Pharmacokinetics; Single dose

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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