Ingramon, a Peptide Inhibitor of MCP-1 Chemokine, Reduces Migration of Blood Monocytes Stimulated by Glioma-Conditioned Medium.
Bull Exp Biol Med
; 160(4): 480-2, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26906197
ABSTRACT
Malignant gliomas are most common and fatal primary brain tumors. In addition to neoplastic cells, the tumor tissue contains microglial cells and monocyte-derived macrophages. It is an established fact that monocyte recruiting promotes the tumor growth and dissemination. Monocyte chemotactic protein-1 (MCP-1) is the major attractant for monocytes. We have previously synthesized an MCP-1 antagonist ingramon, a synthetic peptide fragment (65-76) of this chemokine. In the present study, we demonstrated that glioma-conditioned medium contains MCP-1 and stimulates migration of blood monocytes. Ingramon inhibited the effect of glioma-conditioned medium on monocyte migration.
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MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Linfócitos
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Monócitos
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Quimiotaxia
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Meios de Cultivo Condicionados
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Quimiocina CCL2
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Glioma
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Macrófagos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article