Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells.
F1000Res
; 42015.
Article
em En
| MEDLINE
| ID: mdl-26918147
ABSTRACT
Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.
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MEDLINE
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En
Ano de publicação:
2015
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Article