The effect of titrated fentanyl on suppressed cough reflex in healthy adult volunteers.
Anaesthesia
; 71(5): 529-34, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26919658
ABSTRACT
Cough suppression is part of the pharmacodynamic profile of opioids. We investigated the impact of clinical doses of fentanyl on suppressing the cough reflex. Thirteen volunteers received 2 µg.kg(-1) of fentanyl in a divided administration protocol. Three minutes after each administration and at 10 min intervals during washout, suppressed cough reflex testing with nebulised citric acid was performed and compared with fentanyl effect-site concentration. Mean (SD) citric acid concentration provoking cough increased from 0.5 (0.28) mol.l(-1) at baseline to 1.2 (0.50) mol.l(-1) after 2 µg.kg(-1) of fentanyl (p = 0.01). Mean (SD) fentanyl effect-site concentration after the final dose of fentanyl was 1.89 (0.05) ng.ml(-1) . A strong positive correlation was found between suppressed cough reflex thresholds and fentanyl effect-site concentrations during both fentanyl administration and washout phases of the study (r(2) = 0.79, p = 0.01). The mean (SD) length of time for return of suppressed cough response was 44.6 (18.8) min. Clinically relevant doses of fentanyl produced cough reflex suppression in healthy volunteers.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reflexo
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Fentanila
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Tosse
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Analgésicos Opioides
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article