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Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Huskey, Su-Er W; Zhu, Chun-qi; Lin, Melissa M; Forseth, Ry R; Gu, Helen; Simon, Oliver; Eggimann, Fabian K; Kittelmann, Matthias; Luneau, Alexandre; Vargas, Alexandra; Li, Hongmei; Wang, Lai; Einolf, Heidi J; Zhang, Jin; Favara, Sarah; He, Handan; Mangold, James B.
Afiliação
  • Huskey SE; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Zhu CQ; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Lin MM; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Forseth RR; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Gu H; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Simon O; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Eggimann FK; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Kittelmann M; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Luneau A; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Vargas A; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Li H; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Wang L; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Einolf HJ; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Zhang J; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Favara S; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • He H; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
  • Mangold JB; Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, New Jersey (S.-E.W.H., C.Z., R.R.F., H.G., H.L., L.W., H.J.E., J.Z., S.F., H.H., J.B.M.); Technical Research and Development, Novartis Pharma, East Hanover, NJ (M.M.L.); Novartis Institute for Tropical D
Drug Metab Dispos ; 44(5): 653-64, 2016 May.
Article em En | MEDLINE | ID: mdl-26921386
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Indóis / Malária Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Indóis / Malária Idioma: En Ano de publicação: 2016 Tipo de documento: Article