Confined blood chimerism in a monochorionic dizygotic sex discordant twin pregnancy conceived after induced ovulation.
Birth Defects Res A Clin Mol Teratol
; 106(4): 298-303, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26931099
ABSTRACT
BACKGROUND:
Monochorionic twins are generally considered as a monozygotic twin pregnancy. However, several cases of monochorial dizygotic twin pregnancies have been reported. CASE REPORT We report on a rare case of monochorionic dizygotic twin pregnancy conceived after induced ovulation in a 32-year-old woman. The diagnosis was made on morphological ultrasound examination at 18+4 weeks of gestation, showing two fetuses with discordant sex. The amniocentesis was declined by the patient.RESULTS:
The monochorionic status was confirmed after a histopathalogical study of the placenta. At delivery, both a phenotypically normal boy and a phenotypically normal girl without sexual abnormality were observed. This analysis also revealed the presence of vascular anastomoses between both fetal circulations. Postnatal cytogenetic analyses indicated the presence of a chimerism in peripheral blood lymphocytes. This chimerism was not observed in cells obtained from a buccal swab. Molecular determination of zygosity confirmed the existence of the confined peripheral blood chimerism with the presence of four parental alleles.CONCLUSION:
We report on a case of monochorionic dizygotic twin pregnancy. This observation underlies the need to carefully assess twin pregnancies, especially when obtained after assisted reproductive technology.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gêmeos Dizigóticos
/
Quimerismo
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article