Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis.
J Neural Transm (Vienna)
; 123(5): 491-4, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26931622
ABSTRACT
Rasagiline, a neuroprotective inhibitor of type B monoamine oxidase, prevented PK111195-induced apoptosis in SH-SY5Y cells through inhibition of mitochondrial apoptosis signaling (J Neural Transm 1201539-1551, 2013, J Neural Transm 1221399-1407, 2015). This paper presents that PK11195 induced superoxide flashes, the transit production burst, mediated by cyclosporine A-sensitive membrane permeability transition. Rasagiline prevented superoxide flashes, calcium efflux, and cell death by PK11195. Regulation of the initial pore formation at the inner mitochondrial membrane was confirmed as the decisive mechanism of neuroprotection by rasagiline.
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MEDLINE
Assunto principal:
Apoptose
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Superóxidos
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Fármacos Neuroprotetores
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Membranas Mitocondriais
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Indanos
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Isoquinolinas
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Antineoplásicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article