Preparation of a paclitaxel-loaded cationic nanoemulsome and its biodistribution via direct intratumoral injection.

Xu, Yurui; Asghar, Sajid; Li, Hongying; Chen, Minglei; Su, Zhigui; Xu, Yangfan; Ping, Qineng; Xiao, Yanyu

Xu, Yurui; Asghar, Sajid; Li, Hongying; Chen, Minglei; Su, Zhigui; Xu, Yangfan; Ping, Qineng; Xiao, Yanyu.

Afiliação

Xu Y; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Asghar S; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Li H; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Affiliated Hospital of Weifang Medical University, Weifang 261031, PR China.
Chen M; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Su Z; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Xu Y; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Ping Q; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Xiao Y; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: cpuyanyuxiao@163.com.

Colloids Surf B Biointerfaces ; 142: 81-88, 2016 Jun 01.

Article em En | MEDLINE | ID: mdl-26938323

Assuntos

Antineoplásicos Fitogênicos/farmacocinética; Compostos de Cetrimônio/química; Portadores de Fármacos; Lipídeos/química; Paclitaxel/farmacocinética; Animais; Antineoplásicos Fitogênicos/farmacologia; Área Sob a Curva; Cetrimônio; Composição de Medicamentos; Humanos; Concentração Inibidora 50; Injeções Intralesionais; Células MCF-7; Masculino; Camundongos; Micelas; Paclitaxel/farmacologia; Tamanho da Partícula; Propriedades de Superfície; Distribuição Tecidual; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Body distribution; Cetyltrimethylammonium bromide; Intratumoral drug delivery; Nanoemulsome; Pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Compostos de Cetrimônio / Paclitaxel / Lipídeos / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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