Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation.
Am J Ther
; 23(6): e1579-e1585, 2016.
Article
em En
| MEDLINE
| ID: mdl-26938753
ABSTRACT
Renal transplantation is the treatment of choice for many patients with end-stage renal disease. Because there is little information about depression after kidney transplantation, we investigated frequency and determinant factors of depression and also its association with interleukin (IL)-18. Kidney transplant recipients were investigated between January 2011 and February 2013. Depression was assessed using the Beck Depression Inventory (BDI, BDI-II). We investigated the relationship between 1-year posttransplantation depression and all-cause mortality, acute kidney injury, and serum creatinine 1, 3, and 12 months after transplantation. Furthermore, the association of depression with IL-18 biomarker was recorded 1 year after transplantation. A total of 74 patients (age 37.06 ± 16.2 years; 59.5% male) were enrolled in this study 1 year after transplantation. Nineteen (25.6%), 2 (2.7%), and 1 (1.3%) of them experienced mild, moderate, and severe depression, respectively. IL-18 biomarker (independent variable) was significantly associated with depression 1 year after transplantation. Our data suggested that IL-18 level increased significantly in renal transplant patients with depression.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Interleucina-18
/
Depressão
/
Transplantados
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article