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Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis.
Makafe, Gaëlle Guiewi; Cao, Yuanyuan; Tan, Yaoju; Julius, Mugweru; Liu, Zhiyong; Wang, Changwei; Njire, Moses M; Cai, Xingshan; Liu, Tianzhou; Wang, Bangxing; Pang, Wei; Tan, Shouyong; Zhang, Buchang; Yew, Wing Wai; Lamichhane, Gyanu; Guo, Jintao; Zhang, Tianyu.
Afiliação
  • Makafe GG; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Cao Y; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China School of Life Sciences, Anhui University, Hefei, China.
  • Tan Y; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, The Guangzhou Chest Hospital, Guangzhou, China.
  • Julius M; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Liu Z; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Wang C; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Njire MM; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Cai X; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, The Guangzhou Chest Hospital, Guangzhou, China.
  • Liu T; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China School of Life Sciences, University of Science and Technology of China, Hefei, China.
  • Wang B; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China School of Life Sciences, Anhui University, Hefei, China.
  • Pang W; Langfang Yanjing Vocational and Technical College, Langfang, China Forensic Medical Center, University of Maryland, Baltimore, Maryland, USA.
  • Tan S; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, The Guangzhou Chest Hospital, Guangzhou, China.
  • Zhang B; School of Life Sciences, Anhui University, Hefei, China.
  • Yew WW; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.
  • Lamichhane G; School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Guo J; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China.
  • Zhang T; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, China zhang_tianyu@gibh.ac.cn.
Antimicrob Agents Chemother ; 60(5): 3202-6, 2016 05.
Article em En | MEDLINE | ID: mdl-26953211
We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is a determinant of bacillary susceptibilities to LZD and PNU.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Ribossômicas / Oxazolidinonas / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Ribossômicas / Oxazolidinonas / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2016 Tipo de documento: Article