Polymorphism of Amyloid Fibrils In Vivo.
Angew Chem Int Ed Engl
; 55(15): 4822-5, 2016 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-26954430
ABSTRACT
Polymorphism is a wide-spread feature of amyloid-like fibrils formed inâ
vitro, but it has so far remained unclear whether the fibrils formed within a patient are also affected by this phenomenon. In this study we show that the amyloid fibrils within a diseased individual can vary considerably in their three-dimensional architecture. We demonstrate this heterogeneity with amyloid fibrils deposited within different organs, formed from sequentially non-homologous polypeptide chains and affecting human or animals. Irrespective of amyloid type or source, we found inâ
vivo fibrils to be polymorphic. These data imply that the chemical principles of fibril assembly that lead to such polymorphism are fundamentally conserved inâ
vivo and inâ
vitro.
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Base de dados:
MEDLINE
Assunto principal:
Amiloide
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article