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The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
Stauss, Dennis; Brunner, Cornelia; Berberich-Siebelt, Friederike; Höpken, Uta E; Lipp, Martin; Müller, Gerd.
Afiliação
  • Stauss D; Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
  • Brunner C; Department of Physiological Chemistry, Department of Oto-Rhino-Laryngology Head and Neck Surgery, University of Ulm, Ulm, Germany.
  • Berberich-Siebelt F; Institute of Pathology, University of Würzburg, Würzburg, Germany.
  • Höpken UE; Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
  • Lipp M; Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
  • Müller G; Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany g.mueller@mdc-berlin.de.
EMBO J ; 35(8): 881-98, 2016 Apr 15.
Article em En | MEDLINE | ID: mdl-26957522
Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4(+)T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and Tfh cell development. We found that Bob1 together with the octamer transcription factors Oct1/Oct2 can directly bind to and transactivate theBcl6andBtlapromoters. Mixed bone marrow chimeras revealed that Bob1 is required for the expression of normal levels of Bcl6 andBTLA, thereby controlling the pool size and composition of the Tfh compartment in a T cell-intrinsic manner. Our data indicate that T cell-expressed Bob1 is directly involved in Tfh cell differentiation and required for mounting normal T cell-dependent B-cell responses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Linfócitos T Auxiliares-Indutores / Proteínas de Ligação a DNA Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Linfócitos T Auxiliares-Indutores / Proteínas de Ligação a DNA Idioma: En Ano de publicação: 2016 Tipo de documento: Article