[Insulin secretion and hepatic extraction in juvenile non-insulin-dependent diabetes]. / Secrezione insulinica ed estrazione epatica nel diabete non insulino dipendente giovanile.
Minerva Endocrinol
; 14(3): 177-83, 1989.
Article
em It
| MEDLINE
| ID: mdl-2695816
ABSTRACT
Beta-cell secretion is still a point of controversy. As the liver is the major site of insulin metabolism, evaluation of hepatic insulin extraction is crucial for correct measurement of beta-cell secretion. Methods for calculating the secretion and hepatic extraction of insulin indirectly from peripheral C-peptide concentration have been proposed by some investigators. To characterize the low insulin response of a group of young non-insulin-dependent diabetics we evaluated secretion and hepatic insulin extraction during an oral glucose tolerance test by peripheral IRCP determination and IRCP/IRI molar ratio. Our data show that in this population of young non-insulin-dependent diabetics, the low peripheral insulin response to an oral glucose challenge is a possible consequence of diminished beta-cell secretion, as hepatic insulin extraction is at near normal value.
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Base de dados:
MEDLINE
Assunto principal:
Ilhotas Pancreáticas
/
Diabetes Mellitus Tipo 2
/
Insulina
/
Fígado
Idioma:
It
Ano de publicação:
1989
Tipo de documento:
Article