&#945;B-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5.

Huang, Yuan; Wang, Zhijie; Liu, Yinan; Xiong, Hongbo; Zhao, Yuanyuan; Wu, Ling; Yuan, Chao; Wang, Longfei; Hou, Yuxi; Yu, Gang; Huang, Zhengrong; Xu, Chengqi; Chen, Qiuyun; Wang, Qing K

αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5.

Huang, Yuan; Wang, Zhijie; Liu, Yinan; Xiong, Hongbo; Zhao, Yuanyuan; Wu, Ling; Yuan, Chao; Wang, Longfei; Hou, Yuxi; Yu, Gang; Huang, Zhengrong; Xu, Chengqi; Chen, Qiuyun; Wang, Qing K.

Afiliação

Huang Y; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Wang Z; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Liu Y; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Xiong H; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhao Y; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Wu L; the Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, the Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, and Department of Genetics and Genome Sciences, Case Western Reserve Univ
Yuan C; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Wang L; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Hou Y; the Department of Cardiology, First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003 Xiamen, China.
Yu G; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Huang Z; the Department of Cardiology, First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003 Xiamen, China.
Xu C; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China.
Chen Q; the Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, chenq3@ccf.org.
Wang QK; From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China, the Center for Cardiovascular Genetics, Dep

J Biol Chem ; 291(21): 11030-41, 2016 May 20.

Article em En | MEDLINE | ID: mdl-26961874

Assuntos

Canal de Sódio Disparado por Voltagem NAV1.5/química; Canal de Sódio Disparado por Voltagem NAV1.5/metabolismo; Cadeia B de alfa-Cristalina/química; Cadeia B de alfa-Cristalina/metabolismo; Animais; Linhagem Celular; Membrana Celular/metabolismo; Complexos Endossomais de Distribuição Requeridos para Transporte/química; Complexos Endossomais de Distribuição Requeridos para Transporte/genética; Complexos Endossomais de Distribuição Requeridos para Transporte/metabolismo; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Miocárdio/metabolismo; Canal de Sódio Disparado por Voltagem NAV1.5/genética; Ubiquitina-Proteína Ligases Nedd4; Ligação Proteica; Domínios e Motivos de Interação entre Proteínas; Estabilidade Proteica; Transporte Proteico; Ratos; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Ubiquitina-Proteína Ligases/química; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinação; Cadeia B de alfa-Cristalina/genética

Palavras-chave

Nav1.5; SCN5A; cardiovascular disease; electrophysiology; patch clamp; sodium channel; ubiquitylation (ubiquitination); αB-crystallin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cadeia B de alfa-Cristalina / Canal de Sódio Disparado por Voltagem NAV1.5 Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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